The track of vitamin D, against Covid-19, is out of nowhere. In January 2021, already, 73 experts and six learned societies, gathered around Prof. Cédric Annweiler, head of the geriatrics department at the University Hospital of Angers (Maine-et-Loire), and Prof. Jean-Claude Souberbielle, of the Necker Hospital in Paris, highlighted his efficiency in the fight against the virus.
A new study, called COVIT-TRIAL and published this Tuesday, May 31, in the scientific journal Plos Medicinebrings an extra stone to the building, and confirms the usefulness of vitamin D, in addition to other standard treatments.
“Very high level of evidence”
Initiated by Prof. Annweiler and piloted by Angevin University Hospitalthe latter “With a very high level of evidence, it shows the value of a high dose of vitamin D, given within 72 hours of diagnosis of Covid-19, to frail elderly people who have contracted the infection.”
Between April and December 2020, 260 patients, spread across nine French hospitals and their Ehpads, were solicited. It was, as Prof Annweiler points out, that “Patients aged 65 years and older with Covid-19 with adverse outcome criteria”, et “Patients 75 years of age and older with Covid-19 without any other risk factor.”
Two groups, two different doses
They were randomly divided into two groups. One receiving a high dose of vitamin D within 72 hours of diagnosis; the other receiving a much lower dose, always within the same time frame.
Review: “The administration of the high dose of vitamin D. […] resulted in a significant and statistically significant reduction in the risk of death on the sixth day after starting treatment. » The authors of the study therefore recommend reaching “Satisfactory vitamin D status in the elderly with Covid-19 as soon as possible, with high-dose supplementation as soon as it is diagnosed.”
Limits to profits
However, if a decrease in death to 14 days is recorded, this benefit is no longer observed after 28 days. The study authors suggest studying the effect of regular vitamin D supplementation after the initial high dose. They also state that the purpose of the study was not the possible preventive effect of vitamin D against severe symptoms of Covid-19. Useful, however, vitamin D is not a panacea.